When dozens of holes appeared in a patient's femur alongside his hip prosthesis, experts were baffled as such a phenomenon had never been seen before. Over the first four decades of total hip surgery, the severe bone destruction multiplied, crippling many thousands of patients. Eventually identified as "periprosthetic osteolysis," this devastating disease affected over 1 million patients and was the leading cause of failure in total hip surgery. While total hip surgery dramatically reversed severe arthritis of the hip, the same operation simultaneously created a relentless 'particle generator' in the body. Ironically, in the effort to do good, doctors were simultaneously doing major harm. Vanishing Bone: Conquering a Stealth Disease Caused by Total Hip Replacements takes readers on a detective adventure in contemporary medical science, from the identification of the cause of the disease through the complex process of affecting its cure. Dr. William H. Harris and his colleagues played an important role in solving the mystery of this disease, pointing to its molecular biology, recognizing the unusual wear of the prostheses, and ultimately developing a new material for use in the manufacture of hip implants. With more than 6 million people walking on this stable, low-wear material, the disease has been virtually eliminated among those with total hip replacements worldwide. Diseases are rarely observed, revealed, and eliminated in one lifetime. Vanishing Bone tells the captivating story of one such disease through an engaging account of scientific and medical innovation.

About the Author
William H. Harris, MD, DSc is the Alan Gerry Clinical Professor of Orthopaedic Surgery, Emeritus at Harvard Medical School and Massachusetts General Hospital in Boston, Massachusetts. The Harris Orthopaedic Laboratory at Massachusetts General was founded in 1969 and directed by Dr. Harris until 2004.

Reviews
The purpose is to artfully recreate the evolution of the tackling of a medical problem, prosthetic osteolysis...This is a dynamic, well-written book. It is written more for the lay person, but medical workers will love it as well. It is an essential book not only for a medical library, but also for every library and bookstore. * Samuel J. Chmell, MD, Doody's *
This book chronicles the quest to find a solution to one of the most common causes of long term failure of total hip replacement. William Harriss book on periprosthetic osteolysis is not only a must read for hip surgeons young and old, but will also be of interest to scientists, engineers and patients who have undergone one of the worlds most successful operations. * Phil Hopgood, Consultant Orthopaedic Surgeon, Norfolk and Norwich University Hospital *



Book Information
ISBN 9780190687762
Author William H. Harris
Format Hardback
Page Count 248
Imprint Oxford University Press Inc
Publisher Oxford University Press Inc
Weight(grams) 476g
Dimensions(mm) 211mm * 147mm * 28mm