Description
Sabine Stubler compares different proteasome isoforms and subtypes in terms of their transport and active site-related parameters applying an existing computational model. In a second step, the author extends this model to be able to describe the influence of proteasome inhibitors in in vitro experiments. The computational model, which describes the hydrolysis of short fluorogenic peptides by the 20S proteasome, is calibrated to experimental data from different proteasome isoforms using an approximate Bayesian computation approach. The dynamics of proteasome inhibitors are included into the model in order to demonstrate how to modulate the inhibitor's transport parameters for strong or isoform-specific inhibition.
About the Author
Sabine Stubler works as PhD student in the Computational Physiology Group at the Institute of Biochemistry and Biology, University of Potsdam. Her research focus currently is on developing a novel systems pharmacology model.
Book Information
ISBN 9783658201661
Author Sabine Stubler
Format Paperback
Page Count 96
Imprint Springer Spektrum
Publisher Springer Fachmedien Wiesbaden
