Description
In this fascinating and innovative book, Hogan describes the history of the 'physical map' of the human genome. His interlocked stories neatly illustrate the passage from very partial and crude visualization of human chromosomes to sophisticated genomic technologies of the twenty-first century while maintaining a focus on the chromosomes as the material frame of understanding genetic pathologies. -- Ilana Lowy, CERMES 3, author of Preventive Strikes: Women, Precancer, and Prophylactic Surgery How do we know what our genes tell us? In rich detail, Andrew Hogan reveals the technical, social, epistemological, cartographic, and clinical work that has produced our modern understandings of genetic medicine. In doing so he uncovers the challenges and limitations of our increasing reliance on genetic data in medical decision making. -- Shobita Parthasarathy, Author of Building Genetic Medicine With historical depth and analytical rigor, Hogan traces the development of a twenty-first century genomic gaze that incorporates clinical knowledge, molecular biology, and the durable iconography of human chromosomes. Focusing on several genetic conditions that can be detected prenatally, he deftly connects modern clinical genetics to questions of disease etiology and prevention that have far-reaching ethical and societal implications. -- Alexandra Minna Stern, Author of Telling Genes: The Story of Genetic Counseling in America This engaging book tells a story we've been missing from the history of biomedicine. Hogan brings to life the micro-geography of chromosomes, and those who know them intimately as work objects. This intricate account of genetic syndromes in-the-making shows the continuing relevance of cytogenetic scaffolding to contemporary genomics. -- Aryn Martin, York University
About the Author
Andrew J. Hogan is an assistant professor in the Department of History at Creighton University.
Reviews
By presenting a historical review of the critical scientific literature for these clinical examples, the narrative provides an excellent demonstration of the sequential, developmental process of scientific discovery and acceptance of disease mechanisms... Recomended. Choice
Book Information
ISBN 9781421420745
Author Andrew J. Hogan
Format Hardback
Page Count 280
Imprint Johns Hopkins University Press
Publisher Johns Hopkins University Press
Weight(grams) 522g
Dimensions(mm) 229mm * 152mm * 24mm