Biochemistry

In the mid 80's type I and II enzymes were found to be the intracellular targets of a number of efficacious anticancer drugs such as doxorubicin, mitoxantrone, etoposide and camptothecin as a result of a continued efforts of many investigators,...

Interest in epitope mapping, or finding out where antibodies bind to their antigens, is by no means restricted to immunologists, but is shared by biolo gists from a wide range of disciplines in which antibodies are used as molecu lar reagents. The...

In recent years there has been a tremendous increase in our understanding of the functioning of the cell at the molecular level. This has been achieved in the main by the invention and development of new methodology, parti- larly in that area generally...

International concern in scientific, industrial, and governmental communi ties over traces of xenobiotics in foods and in both abiotic and biotic en vironments has justified the present triumvirate of specialized publications in this field: comprehensive...

International concern in scientific, industrial, and governmental communi ties over traces of xenobiotics in foods and in both abiotic and biotic envi ronments has justified the present triumvirate of specialized publications in this field: comprehensive...

It is by no means a revelation that proteins are not uniformly distributed throughout the cell. As a result, the idea that protein molecules, because of the specificity with which they can engage in interactions with other proteins, may be aimed-via...

The reception of the original volume by students, pedagogues, and reviewers has been most gratifying. It appears to have both satisfied a need and served a useful educational purpose. Hence, some ten years later it has been deemed advisable to bring it...

Cell membranes are not, as once believed, inert structures designed to contain the cell contents, but are in fact dynamic structures that are as me- bolically active as the cytosol and other cellular compartments they surround. Thus membranes not only...

The student of biological science in his final years as an undergraduate and his first years as a graduate is expected to gain some familiarity with current research at the frontiers of his discipline. New research work is published in a perplexing...

Since 1975, when the University of Oklahoma faculty created their review course for second-year medical students, the Oklahoma Notes have been among the most trusted and widely used reviews for the National Boards. Each Oklahoma Notes book presents the...

This volume provides an exhaustive review of the most current knowledge of the composition, architecture and dynamics of the nuclear envelope. In contrast to other comprehensive works on cellular membranes in general, this book is the first to...

Bioinformatics is a relatively new field of research. It evolved from the requirement to process, characterize, and apply the information being produced by DNA sequencing technology. The production of DNA sequence data continues to grow exponentially. At...

Many fundamental aspects of the methods used in mass spectrometry are presented here, with reference to recent developments. The principles and applications of electrospray, ion spray and MALDI ionization technique are included, together with optimised...

Gathering together a number of experts in the world, the 27th Jerusalem Symposium was devoted to the theme of the modelling of biomolecular structures and mechanisms. As a result of recent growth in both importance and audience, the papers contained in...

That residues of pesticide and other contaminants in the total environ ment are of concern to everyone everywhere is attested by the reception accorded previous volumes of "Residue Reviews" and by the gratifying enthusiasm, sincerity, and efforts shown...

Advances in biochemistry, cell biology, genome-wide mutagenesis - coupled with molecular technology, including gene microarray and transgenic and knock-out animals - have been instrumental in understanding the cellular processes and molecular pathways of...

This volume represents a collection of lectures delivered by outstanding specialists in the fields of biophysics and of related scientific disciplines th during the 7 International Summer School on Biophysics held in Rovinj, Croatia from 14 to 25...

There has been a considerable upsurge in interest in insect bio chemistry and physiology in recent years and this has been reflected in a notable expansion in the number of original papers in this field. Whereas insect physiology has tended to receive...

Genetics and You will illuminate once and for all the mysteries of genetics and genetic abnormalities, inspiring you with the understanding and confidence you need to successfully deal with the troubling dilemmas inherited disease creates.Book...

X-ray crystallography is an established method for studying the structure of proteins and other macromolecules. As the importance of proteins grows, researchers in many fields have found that a working knowledge of X-ray diffraction is an indispensable...

Endocrinology is a field in which enormous advances have been made in the last decade; the rate of discovery of new hormones, hormone-like molecules, receptors, and mechanisms of action is continually advancing. The development of techniques in...

International concern in scienti? c, industrial, and governmental commu- ties over traces of xenobiotics in foods and in both abiotic and biotic en- ronments has justi? ed the present triumvirate of specialized publications in this ? eld: comprehensive...

The contributors to this manual are uniformly from those labora- ries routinely using microwave technology to facilitate their processing methods in the various fields of microscopy. The methods and results these authors describe are the tangible...

The development of PCR, which enables extremely small amounts of DNA to be amplified, led to the rapid development of a multiplicity of a- lytical procedures to utilize this new resource for analysis of genetic variation and for the detection of disease...

This book presents the statistical methods that are useful in the study of molecular evolution and illustrates how to use them in actual data analysis. Molecular evolution has been developing at a great pace over the past decade or so, driven by the huge...

The frequency of reports concemmg the interface of biological reco- tion elements to signal transduction technologies has risen dramatically over the last decade. Because any one of a wide variety of biological recognition elements (e. g. , antibodies,...

International concern in scientific, industrial, and governmental communities over traces of xenobiotics in foods and in both abiotic and biotic environments has justified the present triumvirate of specialized publications in this field: comprehensive...

International concern in scientific, industrial, and governmental communities over traces of xenobiotics in foods and in both abiotic and biotic environments has justified the present triumvirate of specialized publications in this field: comprehensive...

Man's mind stretched to a new idea never goes back to its original dimensions Oliver Wendell Holmes Our current understanding of sex and biological differentiation results from the application of three principal experimental approaches to these subjects:...

This book represents the proceedings of a Satellite Symposium of the XIth International Congress of Biochemistry on "Control of Membrane Fluidity" which was held on July 7, 1979 at the Charles H. Best Institute, University of Toronto, Toronto, Canada...

We are in a phase of the evolution of biotechnology in which the true and potential commercial importance of carbohydrates is becoming appre- ated more fully. Progress in providing hard facts to establish the commercial value ofpolysaccharides and...

Reviews of Environmental Contamination and Toxicology provides concise, critical reviews of timely advances, philosophy and significant areas of accomplished or needed endeavor in the total field of xenobiotics, in any segment of the environment, as well...

New textbooks at all levels of chemistry appear with great regularity. Some fields like basic biochemistry, organic reaction mechanisms, and chemical thermodynamics are well represented by many excellent texts, and new or revised editions are published...

MANY aspects of physiology are best understood in terms of bodily reactions to environmental stress, and temperature is one of the most often encountered stress factors in the environment. The responses to temperature can involve practically all of the...

The lipases and phospholipases represent a diverse group of enzymes that are expressed in animals, plants, fungi, and bacteria. Their ubiquitous distribution among all species is a testament to the essential roles played by these enzymes in lipid...

Extracellular Glycolipids of Yeasts: Biodiversity, Biochemistry, and Prospects provides a comprehensive view of the biochemistry, biological activity, and practical application of extracellular glycolipids of yeast. This book brings much-needed clarity...

The central purpose of this combination lecture/laboratory manual is to present detailed protocols for the multi-step process involved in isolating a gene, cloning and characterizing it, expressing the encoded protein, purifying the protein, and...

As studies using microarray technology have evolved, so have the data analysis methods used to analyze these experiments. The CAMDA (Critical Assessment of Microarray Data Analysis) conference was the first to establish a forum for a cross section of...

Reviews of Environmental Contamination and Toxicology attempts to provide concise, critical reviews of timely advances, philosophy, and significant areas of accomplished or needed endeavor in the total field of xenobiotics in any segment of the...

RAN: AN ATYPICAL GTPASE Mark G. Rush and Peter D'Eustachio New York University School o/Medicine. Department,o/Biochemistry New York NY 10016 ABSTRACT GTPases, proteins that bind and hydrolyze GTP (guanosine triphos- phate) are critical regulators of...