The Gnotobiotic pig model is the most reliable animal model for evaluating human rotavirus and norovirus vaccines. To better mimic humans, human gut microbiota are transplanted pig models for rotaviral and noroviral vaccines. These models are used to evaluate the immunogenicity and protective efficacy of these vaccines. This book to provides information on various aspects of establishing Gnotobiotic pig models, establishing a virus inoculum pool, determining proper challenge dose in these models, measuring protection and calculating protective efficacy, and delineating intestinal and systemic immune responses associated with the protection. Key Features Provides guidance on how to establish Gnotobiotic pig models Illustrates the use of an animal model to test protective efficacy and safety in the development of vaccines Documents the reliablity of the gnotobiotic pig model system Compares the efficacy of oral rotoviral vaccines to other immunization routes Describes the role of the human gut microbiome in protective efficacy of human rotoviral vaccines

Book Information
ISBN 9780367486341
Author Lijuan Yuan
Format Paperback
Page Count 184
Imprint CRC Press
Publisher Taylor & Francis Ltd