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Population Genomics in the Developing World: Concepts, Applications, and Challenges Marlo Möller 9780443185465

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Description

Population Genomics in the Developing World: Concepts, Applications, and Challenges, a new volume in the Translational and Applied Genomics series, provides a comprehensive, up-to-date summary of the field of population genomics in developing countries. The book equips students, researchers, and clinicians with the practical skills and approaches necessary to face the unique challenges and opportunities of practicing population genomics in developing countries. Following a brief foundational overview, more than a dozen authors working in developing nations share applied case studies from the field, including rationale, methods, analysis, and outcomes to reinforce understanding. Key themes across the country specific chapters include efficient genetic data generation and effective computational and statistical tools to analyze population-level data. The book then discusses clinical interpretation of this data, from direct-to-consumer ancestry testing to translational and applied precision medicine. A final chapter considers ethical aspects of conducting genomic research in developing countries.

About the Author
Dr. Marlo Moeller's primary research focuses on finding the genetic underpinnings of tuberculosis (TB). She developed an interest in this field at the beginning of her postgraduate degrees and continued this focus throughout her postdoctoral studies. She is currently an Associate Professor at Stellenbosch University, in Stellenbosch, South Africa. Her investigations into the genetic contribution of the human host to individual and population susceptibility to tuberculosis include tuberculous meningitis, tuberculosis resisters, the role of ancestry in tuberculosis disease, and primary immunodeficiencies. Dr. Moeller's work leverages the complex ancestry of the admixed people in South Africa, specifically the unique genetic contribution from hunter-gatherer ancestry, to find novel genes and pathways involved in TB resistance and susceptibility. Dr. Caitlin Uren currently works in the fields of human population genetics, bioinformatics, and communicable and noncommunicable diseases. Her initial research focused on identifying and characterizing genetic population structure in southern African human populations. This information was then used in the development of novel computational pipelines. In addition, she has been involved in the analysis of next-generation sequencing data with the goal to provide a molecular diagnosis to patients with suspected genetic disorders. She is currently involved in numerous projects that encompass data repositories, bioethics, bioinformatics, pharmacogenetics, and population genetics. As an early-career researcher, it is her goal to further the human genetics field in Africa and to teach and guide the next generation of scientists. George P. Patrinos is Professor of Pharmacogenomics and Pharmaceutical Biotechnology in the University of Patras (Greece), Department of Pharmacy, Head of Division of Pharmacology and Biosciences of the same Department and holds adjunct Full Professorships at Erasmus MC, Faculty of Medicine, Rotterdam (the Netherlands) and the United Arab Emirates University, College of Medicine, Department of Genetics and Genomics, Al-Ain (UAE). Also, since March 2018, he is Chair of the Global Genomic Medicine Collaborative (G2MC) and since May 2023 Chairman of the Scientific Advisory Board of the ASPIRE Abu Dhabi Precision Medicine Research Institute. He has ample regulatory experience, as he served for 12.5 years as Full Member and Greece's National representative in the CHMP Pharmacogenomics Working Party of the European Medicines Agency (EMA) and he is still an active member of the European Medicines Agency participating in expert panels to provide scientific advice where needed. George is currently Director of the Laboratory of Pharmacogenomics and Individualized Therapy, the first officially established academic pharmacogenomics laboratory in Greece. His group has keen interest in research covering disciplines from wet and dry lab and public health genomics projects, all focusing on pharmacogenomics and personalized medicine. In particular, his research interests involve discovery work and clinical implementation of pharmacogenomics, focusing in particular in psychiatry but also cardiology and oncology, genomics of rare disorders and transcriptional regulation of human fetal globin genes. Moreover, George's group is internationally recognized for its involvement in developing National/Ethnic Genetic databases to document the genetic heterogeneity in different populations worldwide and of genome informatics tools to translate genomic information into a clinically meaningful format. Also, George's group has a keen interest in public health genomics to critically assess the impact of genomics to society and public health. George has more than 330 publications in peer-reviewed scientific journals, some of them in leading scientific journals, such as The Lancet and Lancet EBioMedicine. Also, he has co-authored and co-edited more than 15 textbooks, among which the renowned textbook "Molecular Diagnostics", published by Academic Press, now in its 3rd edition, while he is the editor of "Translational and Applied Genomics" book series, published by Elsevier. Furthermore, since September 2020, he serves as Editor-In-Chief of the prestigious Pharmacogenomics Journal (TPJ), published by Nature Publishing Group, Associate Editor and member of the editorial board of several scientific journals and has been a member of several international boards and advisory and evaluation committees. Apart from that, George is the main co-organizer of the Golden Helix Conferences, an international meeting series on Pharmacogenomics and Genomic Medicine with more than 50 conferences organized in more than 25 countries worldwide.


Book Information
ISBN 9780443185465
Author Marlo Moeller
Format Paperback
Page Count 472
Imprint Academic Press Inc
Publisher Elsevier Science Publishing Co Inc
Weight(grams) 450g

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