Non-pathologists, such as toxicologists and study personnel, can find it difficult to understand the data they receive from pathologists. Toxicological pathologists write long, detailed and highly technical reports. Study personnel are under daily pressure to decide whether lesions described in pathology reports are treatment-related and thus important to the pharmaceutical company or whether the lesions are background changes and thus of little significance.

Written by experienced toxicological pathologists, Pathology for Toxicologists: Principles and Practices of Laboratory Animal Pathology for Study Personnel serves to bridge the gap in the understanding of pathology data, enabling non-pathologists to more easily comprehend pathology reports, better integrate pathology data into final study reports and ask pathologists relevant questions about the test compound.

This succinct, fully referenced, full colour book is suitable for toxicologists at all stages of their training or career who want to know more about the pathology encountered in laboratory animals used in safety studies. Key features include important chapters on spontaneous and target organ lesions in rats, mice, non-human primates, mini pigs, rabbits and beagle dogs as well as information on general pathology, macroscopic target organ lesions, ancillary pathology techniques, haematology, biochemistry and adversity.

Pathology for Toxicologists: Principles and Practices of Laboratory Animal Pathology for Study Personnel includes:

• Colour diagrams explaining how lesions are caused by either external compounds or spontaneously
• The anatomic variations and background lesions of laboratory animals
• Advice on sampling tissues, necropsy, ancillary pathology techniques and recording data
• A chapter on the haematology and biochemistry of laboratory animals
• Full colour photographs of common macroscopic lesions encountered in laboratory animals
• A comprehensive glossary

About the Author

About the Editor
Elizabeth McInnes edited the successful "Background Lesions in Laboratory Animals, A Color Atlas" (2011) and has published widely on various aspects of toxicological pathology. She qualified as a veterinary surgeon in South Africa in 1988 and completed a PhD at Imperial College, London in 1996. She was awarded Fellowships of the Royal College of Pathologists in 1997 and of the International Academy of Toxicologic Pathology in 2011. She currently runs her own toxicological pathology consultancy business.

Reviews
In its first edition, Pathology for Toxicologists edited by Dr Elizabeth McInnes is a much welcomed addition to the basic literature bridging the 2 complementary sciences of pathology and toxicology, specifically within the context of drug, chemical, or device industries. Aimed at the wide spectrum of study personnel supporting investigational and routine toxicity studies, this book provides a broad yet succinct coverage of the bases underlying the generation and interpretation of pathology data and enables a better use, comprehension, and integration of these data into toxicology reports. In its paperback presentation (provided for this review), the book is illustrated and has a good print quality, is concise, portable, and thoroughly referenced. The 6 contributing authors are all adequately qualified and have hands-on experience on the topics they covered; the editor herself contributed with 4 chapters. The book structure is organized into 8 chapters and include an introduction to pathology techniques, recording pathology data, general pathology and the terminology of basic pathology, common spontaneous and background lesions in laboratory animals, target organ pathology, clinical pathology, adversity from the pathologist's perspective, and limitations of pathology and animal models.Each chapter begins with a learning objectives section and ends with a comprehensive list of references; a chapter-by-chapter analysis is included below. The book also includes a glossary (always helpful when dealing with pathology terms and acronyms)
and an index. In short, this book is a bridging reference between toxicology and pathology, broadly covering the bases of laboratory animal pathology generation, interpretation, and communication, and it should prove useful not only for early career as well as for practicing toxicologists. (International Journal of Toxicology 36:5)

'The book succinctly covers the general underpinnings of pathology data generation and interpretation, with the honorable goal of facilitating the use, communication, understanding, and integration of pathology data into toxicology reports ...Six highly qualified authors contributed with 8 chapters (4 of which were authored by the editor), spanning various themes in pathology data generation and interpretation, including an introduction to pathology techniques, recording pathology data, general pathology and the terminology of basic pathology, common spontaneous and background lesions in laboratory animals, target organ pathology, clinical pathology, adversity from the pathologist's perspective, and limitations of pathology and animal models ... At the beginning of each chapter, a learning objectives box frames the most important concepts to be attained and, at its conclusion, a comprehensive list of references points the reader to additional information. The book is complete with an index and a glossary (a must-have when working with pathology terminology and acronyms). This textbook is a bridging reference covering the general bases of pathology data generation, interpretation, and communication that early career and practicing toxicologists will find useful.' (Journal of Toxicologic Pathology, November 2017)

'Pathology for Toxicologists is highly recommended not only for toxicologist, but also for pharmaceutical research, discovery, and development scientists; young anatomic and clinical toxicologic pathologists; academic and diagnostic pathologists; and anatomic and clinical pathology graduate students and residents. Its use will successfully facilitate the interface between toxicologist and toxicologic pathologists. Its perusal by pharmaceutical research and discovery scientists will facilitate their understanding of the technical constraints and regulatory requirements that face toxicologic pathologists and toxicologic pathology laboratories. Its perusal by young anatomic and clinical toxicologic pathologists upon entry into toxicologic pathology will quickly bring them up-to-speed on the complexity of the regulations and constraints under which they will be working. Perusal of the book by toxicologists and study personnel will provide them an insight into the toxicologic pathology world, improving their interfaces and collaborations and facilitating decisions about pathology.' (Veterinary Clinical Pathology, November 2017)



Book Information
ISBN 9781118755402
Author Elizabeth McInnes
Format Paperback
Page Count 216
Imprint Wiley-Blackwell
Publisher John Wiley and Sons Ltd
Weight(grams) 431g
Dimensions(mm) 244mm * 168mm * 13mm