The purpose of this monograph is to describe recent developments in mathematical modeling and mathematical analysis of certain problems arising from cell biology. Cancer cells and their growth via several stages are of particular interest. To describe these events, multi-scale models are applied, involving continuously distributed environment variables and several components related to particles. Hybrid simulations are also carried out, using discretization of environment variables and the Monte Carlo method for the principal particle variables. Rigorous mathematical foundations are the bases of these tools.The monograph is composed of four chapters. The first three chapters are concerned with modeling, while the last one is devoted to mathematical analysis. The first chapter deals with molecular dynamics occurring at the early stage of cancer invasion. A pathway network model based on a biological scenario is constructed, and then its mathematical structures are determined. In the second chapter mathematical modeling is introduced, overviewing several biological insights, using partial differential equations. Transport and gradient are the main factors, and several models are introduced including the Keller-Segel systems. The third chapter treats the method of averaging to model the movement of particles, based on mean field theories, employing deterministic and stochastic approaches. Then appropriate parameters for stochastic simulations are examined. The segment model is finally proposed as an application. In the fourth chapter, thermodynamic features of these models and how these structures are applied in mathematical analysis are examined, that is, negative chemotaxis, parabolic systems with non-local term accounting for chemical reactions, mass-conservative reaction-diffusion systems, and competitive systems of chemotaxis. The monograph concludes with the method of the weak scaling limit applied to the Smoluchowski-Poisson equation.
Reviews
"This book deals with the mathematical analysis of selected models of reaction-diffusion systems. The book is intended to both graduate as well as advanced undergraduate students in applied mathematics." (Luisa Consiglieri, zbMATH 1397.92005, 2018)

"The author, in this short book, develops a variety of multi-scale mathematical models for cancer cell phenomena that occur at several different stages in the development and progression of cancer. ... this book is a useful addition to the growing literature on the mathematical biology of the evolution and behavior of cancer and tumor cells. This book should appeal to a wide audience of applied mathematicians working in mathematical biology or the applied mathematics of ordinary and partial differential equations." (Jason M. Graham, Mathematical Reviews, November, 2017)



Book Information
ISBN 9789811036705
Author Takashi Suzuki
Format Paperback
Page Count 144
Imprint Springer Verlag, Singapore
Publisher Springer Verlag, Singapore