Enables drug developers in academia and industry to expand the range of accessible drug targets through induced protein degradation

Since the introduction of the PROTAC technology in 2015, targeted protein degradation has greatly increased the range of druggable protein targets, enabling pharma companies to develop completely novel therapeutics. Inducing Targeted Protein Degradation is a timely guide to navigating the complexities of the subject and understanding its practical application, with an eye on expanding the range of druggable targets.

In Inducing Targeted Protein Degradation, readers will find the most recent information on:

• Cellular mechanisms of targeted protein degradation and current approaches to retarget these mechanisms for therapeutic use
• A comparison of different induced degradation approaches, including PROTAC, light-activated degradation, and CHAMPS
• Drug development aspects such as DMPK optimization and selection of clinical candidates
• A discussion of the potential of targeted degradation for expanding the range of druggable protein targets

Inducing Targeted Protein Degradation will serve as a practice-oriented reference on induced protein degradation for drug discovery professionals and for researchers employing chemical biology approaches.

Book Information
ISBN 9783527350131
Author P Cromm
Format Hardback
Page Count 384
Imprint Wiley-VCH Verlag GmbH
Publisher Wiley-VCH Verlag GmbH
Weight(grams) 888g