Neurodegenerative diseases are characterized by progressive structural and/or functional deterioration and eventual death of affected neurons. The progression of these disorders shares similarities at the molecular level. The programmed cell death manifests as blebbing of the plasma membrane, protein degradation, DNA damage, and clearance of dead cells by scavengers. Caspases and Neuronal Apoptosis in Neurodegenerative Diseases begins with an introduction to neurodegenerative diseases detailing their epidemiology and clinical presentation. This is followed by a description of the structural organization of human caspases, their classification, role with mitochondria, and their mechanisms of activation. There is extensive discussion of neuronal apoptosis including its pathways and underlying mechanisms. The book concludes with a chapter on the intricate mechanisms and interplay between human caspases and neuronal apoptosis in neurodegenerative diseases. All of this is undercut with extensive coverage of molecular events in the pathogenesis of neurodegenerative disorders. Biomedical researchers, graduate students, and scientists, as well as neuroscientist and student trainees will greatly benefit from the thorough information this book provides.

Book Information
ISBN 9780128201220
Author Anil Gupta
Format Paperback
Page Count 200
Imprint Academic Press Inc
Publisher Elsevier Science Publishing Co Inc
Weight(grams) 191g