This new edition presents an up-to-date, comprehensive overview of the GABAB receptor system, including a particular focus on the most recent therapeutic applications and potential. This receptor system has been implicated in several diseases and disorders, including gastroesophageal reflux disease, epilepsy, mood disorders, depression, and alcohol and substance use disorder. The authors, leading researchers in the field, explore a number of approaches, including medicinal chemistry, molecular biology, physiology, and preclinical and clinical pharmacology. The new edition is completely reworked and updated, featuring the latest pharmacological advances on baclofen and positive allosteric modulators.

About the Author

Giancarlo Colombo is a researcher at the Neuroscience Institute, National Research Council of Italy, Cagliari, Italy.

His research interest is primarily on neurobiology and pharmacology of alcohol use disorder, with focus on the role of GABAB receptor in the control of multiple alcohol-related behaviors and development of GABAB receptor ligands as possible pharmacotherapies for alcohol use disorder.

He has published approximately 240 papers in peer-reviewed journals and about 20 book chapters; he was also the editor of the 2016 volume on GABAB receptor.

He serves as co-chief-editor of the journal Alcohol and Alcoholism.

Book Information
ISBN 9783031671470
Author Giancarlo Colombo
Format Hardback
Page Count 341
Imprint Humana
Publisher Springer International Publishing AG