Emerging evidence suggests that dendritic cells play a major role in the orchestration of the immune response to bacteria. This volume introduces the reader to the complex world of dendritic cells and describes how the intimate interplay between dendritic cells, bacteria and the environment dictates either the induction of immunity or tolerance to the encountered microorganisms. It discusses how this can allow organisms to tolerate beneficial bacteria and to react against pathogens, as well as the strategies pathogenic bacteria have evolved to escape dendritic cell patrolling. Expert contributors discuss everything from bacterial capture and recognition to their killing, processing and the induction of adaptive immunity. Particular focus is on the tissue context in which bacteria are handled by dendritic cells and on possible defects therein, which may potentially lead to chronic infection or inflammation. Graduate students and researchers will find this an invaluable overview of current dendritic cell biology research.

Research-level overview of dendritic cell-bacterial interactions and the resultant induction of either immunity or tolerance.

About the Author
Maria Rescigno is the Director of the Research Unit at the European Institute of Oncology, Italy. The research focuses on the study of dendritic cell biology and immunotherapy.


Book Information
ISBN 9780521855860
Author Maria Rescigno
Format Hardback
Page Count 266
Imprint Cambridge University Press
Publisher Cambridge University Press
Weight(grams) 565g
Dimensions(mm) 235mm * 160mm * 20mm