Description
Covering theoretical methods and computational techniques in biomolecular research, this book focuses on approaches for the treatment of macromolecules, including proteins, nucleic acids, and bilayer membranes. It uses concepts in free energy calculations, conformational analysis, reaction rates, and transition pathways to calculate and interpret biomolecular properties gleaned from computer-generated membrane simulations. It also demonstrates comparative protein structure modeling, outlines computer-aided drug design, discusses Bayesian statistics in molecular and structural biology, and examines the RISM-SCF/MCSCF approach to chemical processes in solution.
About the Author
Oren M. Becker, Alexander D. MacKerell, Benoit Roux, Masakatsu Watanabe
Reviews
"From the foreword... ...This volume has an important role to play in the transition of the field from one limited to specialists to the mainstream of molecular biology. The emphasis on an in-depth description of the computational methodology will make the volume useful as an introduction to the field for many people who are doing simulations for the first time....A number of well-chosen 'special topics' involving applications of simulation methods are described....several chapters broaden the perspective of the book by introducing approaches other than molecular dynamics for modeling proteins and their interactions....equally important...is the biophysical aspect of computational biology. I am very pleased to have been given the opportunity to contribute a Foreword to this very useful book. It is a particular pleasure for me to do so because all the editors and fifteen of the authors are alumnae of my research group at Harvard, where molecular dynamics simulations of biomolecules originated. " ---Martin Karplus, Laboratoire de chimie Biophysique, ISIS Universite Louis Pasteur, Strasbourg, France, and Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts Promo Copy
Book Information
ISBN 9780367397579
Author Oren M. Becker
Format Paperback
Page Count 512
Imprint CRC Press
Publisher Taylor & Francis Ltd
Weight(grams) 980g
About the Author
Oren M. Becker, Alexander D. MacKerell, Benoit Roux, Masakatsu Watanabe
Reviews
"From the foreword... ...This volume has an important role to play in the transition of the field from one limited to specialists to the mainstream of molecular biology. The emphasis on an in-depth description of the computational methodology will make the volume useful as an introduction to the field for many people who are doing simulations for the first time....A number of well-chosen 'special topics' involving applications of simulation methods are described....several chapters broaden the perspective of the book by introducing approaches other than molecular dynamics for modeling proteins and their interactions....equally important...is the biophysical aspect of computational biology. I am very pleased to have been given the opportunity to contribute a Foreword to this very useful book. It is a particular pleasure for me to do so because all the editors and fifteen of the authors are alumnae of my research group at Harvard, where molecular dynamics simulations of biomolecules originated. " ---Martin Karplus, Laboratoire de chimie Biophysique, ISIS Universite Louis Pasteur, Strasbourg, France, and Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts Promo Copy
Book Information
ISBN 9780367397579
Author Oren M. Becker
Format Paperback
Page Count 512
Imprint CRC Press
Publisher Taylor & Francis Ltd
Weight(grams) 980g
