The binding of antibiotics and drugs to DNA is a fast developing area of research with important applications in medicine, particularly the treatment of cancer. Sequence-specific DNA Binding Agents uniquely discusses key aspects of this topic, providing a novel perspective on the subject. Written by experts in the field, this book discusses diverse modes of binding of antibiotics and drugs to DNA, emphasising matters that are important or promising for cancer treatment. Chapters discuss established agents like actinomycin D but also look at novel drugs with strong potential in chemotherapy such as new topoisomerase inhibitors, telomerase inhibitors, peptide nucleic acids and triple helix-forming oligonucleotides. There are also sections discussing methodological advances including computational methods, slow kinetics, melting curve analysis and approaches to medicinal chemistry. Finally there is a section on RNA structure and its potential as a drug target. The book is ideal for researchers in industry and academia who require a comprehensive source of reference to this rapidly expanding subject.

Reviews

An excellent overview of the work being done in the exciting areas of discovering agents that exhibit selectivity and sequence specificity for DNA.Michael J Waring, who has been a pioneer in and made seminal contributions to this particular field.A comprehensive reference on this rapidly expanding field.....is a must read.....an excellent text book for a graduate course on this subject and a useful guide at the post-graduate level for biochemists as well as biophysicists.

* ChemBioChem, 2007, 8, 459-460 (Fu-Mling Chen) *



Book Information
ISBN 9780854043705
Author Michael J Waring
Format Hardback
Page Count 528
Imprint Royal Society of Chemistry
Publisher Royal Society of Chemistry
Weight(grams) 560g